Problems of Subject Mediator Development for Gene Expression Regulation Domain.
|Author(s): || Kalinichenko L.A., Briukhov D.O, Zakharov V.N., Podkolodnaya O.A., Podkolodny N.L.
|Published:||Proc. of the Fourth Russian Conference on Digital Libraries RCDL'2002. -- Dubna: JINR, 2002. -- V 2. -- P. 94--102. (In Russian)
|For efficient organization of research in the domain of bioinformatics it
is required to organize properly the relevant information in specific research areas.
One of the important outcomes of such organization would be provision of
access to and querying of a large number of distributed information sources including
various data on the primary and spatial structure of DNA and RNA macromolecules,
proteins and their complexes as well as data on peculiarities of
their interactions with each other.
To provide for semantic integration of nonsystematic population of
autonomous information sources kept by different information providers into a
well-structured information collection it is required to create the global unified
representation of the existing information sources and services. To reach that it
is proposed to form a special middleware consisting of the subject mediators.
For each subject mediator, the application domain model is to be defined by the
experts in the field. This model may include specifications of data structures,
terminologies (thesauri), concepts (ontologies), methods applicable to data,
processes (workflows), characteristic for the domain. The mediators provide a
uniform query interface to the multiple data and procedure service sources,thereby freeing the users from having to locate the relevant sources, query each
one in isolation, and combine manually the information from them.
In the paper we discuss an approach for development of the mediator for
integration of heterogeneous molecular-genetic data in the gene expression regulation
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